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Title   방광 이행세포암에서 Membranous E-cadherin 의 임상적 유용성 ( The Clinical Usefulness of Membranous E-cadherin in Transitional Cell Carcinoma of the Bladder )
Publicationinfo   1998 Jan; 030(06): 1219-1227.
Key_word   E-cadherin, Bladder cancer
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Abstract   Purpose: E-cadherin, a cell adhesive molecule that plays a diverse role in cell-cell and cell-matrix interaction, is essential for maintaining epithelial intercellular adhesion and acts particularly as a suppressor of invasive ability of cancer. To detennine the potential pro- gnostic values of membranous E-cadherin, we evaluated the correlation between the clin- ical outcome and its expression in patients with transitional cell carcinoma of the bladder. Materials and Methods: Membranous E-cadherin immunoreactivity was evaluated in 75 cases of transitional bladder cancer and 15 controls (5 cases of cystitis and 10 normal controls). The expression of membranous E-cadherin were compared with histological grade, T category of TNM stage, and survival. Results: Abnonnal immunohistochemical expression of membranous E-cadherin was observed in 53 (70.7%) patients with bladder cancer and undetected in controis. Abnormal immunohistochemical expression of membranous E-cadherin was significantly correlated with grade (p<0.01) and T category of TNM stage (p<0.01) of transitional cell carcinoma of the bladder. Progression to invasive cancer occurred in 6 patients with 45 superficial bladder cancer and 5 of them showed abnormal expression of E-cadherin, which had statistical significance (p<0.05) but not with recurrence. There was statistically significant correlation between the abnormal expression of E-cadherin and poor prognosis (p < 0.01). Conclusions: We conclude that abnormal expression of membranous E-cadherin is a useful prognostic marker in patients with transitional bladder cancer.
저 자   오봉렬(Bong Ryoul Oh),나길주(Gil Joo Nah),김성진(Seong Jin Kim),심재홍(Jae Hong Sim),권동득(Dong Deuk Kwon),박광성(Kwang Sung Park),류수방(Soo Bang Ryu),박양일(Yang Il Park)